Evaluation of Amantadine in the Prophylaxis of Influenza A (H1N1) Virus Infection: A Controlled Field Trial among Young Adults and High-Risk Patients
Identifieur interne : 000927 ( Istex/Curation ); précédent : 000926; suivant : 000928Evaluation of Amantadine in the Prophylaxis of Influenza A (H1N1) Virus Infection: A Controlled Field Trial among Young Adults and High-Risk Patients
Auteurs : R. F. Pettersson [Finlande] ; P.-E. Hellström [Finlande] ; K. Penttinen [Finlande] ; R. Pyh L [Finlande] ; O. Tokola [Finlande] ; T. Vartio [Finlande] ; R. Visakorpi [Finlande]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Abstract
The usefulness of amantadine in the protection of humans against influenza A (H1N1) virus was evaluated in a double-blind field trial with 555 volunteers in Finland in the winter of 1978. Three populations—patients in a general hospital, adults in a home for the aged, and two groups of military conscripts-were chosen. Epidemic influenza occurred only in the two groups of conscripts: the incidence of serologically verified influenza was 66% and 83% in the groups that received placebo and 43% and 51% in the groups that received amantadine, giving protection rates of 36% (P = 0.05) and 39% (P = 0.001). The evaluation of the effect of amantadine on the occurrence of illness was obscured by concomitant adenoviral infections that caused influenza-like symptoms. No clear difference in the occurrences of side effects was observed between the placebo and amantadine-treated groups; however, a significantly greater number of participants who took 200 mg of amantadine/day (16.9%) stopped medication during the trial as compared with the placebo groups (7.6%) (P < 0.02).
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DOI: 10.1093/infdis/142.3.377
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F." last="Pettersson">R. F. Pettersson</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Please address requests for reprints to Dr. R. Pettersson, Department of Virology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29, Finland.</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Please address requests for reprints to Dr. R. Pettersson, Department of Virology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29</wicri:regionArea></affiliation></author><author><name sortKey="Hellstrom, P E" sort="Hellstrom, P E" uniqKey="Hellstrom P" first="P.-E." last="Hellström">P.-E. Hellström</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author><author><name sortKey="Penttinen, K" sort="Penttinen, K" uniqKey="Penttinen K" first="K." last="Penttinen">K. Penttinen</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author><author><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author><author><name sortKey="Tokola, O" sort="Tokola, O" uniqKey="Tokola O" first="O." last="Tokola">O. Tokola</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author><author><name sortKey="Vartio, T" sort="Vartio, T" uniqKey="Vartio T" first="T." last="Vartio">T. Vartio</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author><author><name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name><affiliation wicri:level="1"><mods:affiliation>Department of Virology, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Virology, University of Helsinki, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Central Public Health Laboratory, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Central Public Health Laboratory, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Research Laboratories, Medica Ltd., Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Laboratories, Medica Ltd., Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kustaankartano, Home for the Aged, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Kustaankartano, Home for the Aged, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Section, General Headquarters of the Finnish Defence Forces, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Mjölbolsta Hospital, Mjölbolsta, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Mjölbolsta Hospital, Mjölbolsta</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1980-09">1980</date><biblScope unit="vol">142</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="377">377</biblScope><biblScope unit="page" to="383">383</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The usefulness of amantadine in the protection of humans against influenza A (H1N1) virus was evaluated in a double-blind field trial with 555 volunteers in Finland in the winter of 1978. Three populations—patients in a general hospital, adults in a home for the aged, and two groups of military conscripts-were chosen. Epidemic influenza occurred only in the two groups of conscripts: the incidence of serologically verified influenza was 66% and 83% in the groups that received placebo and 43% and 51% in the groups that received amantadine, giving protection rates of 36% (P = 0.05) and 39% (P = 0.001). The evaluation of the effect of amantadine on the occurrence of illness was obscured by concomitant adenoviral infections that caused influenza-like symptoms. No clear difference in the occurrences of side effects was observed between the placebo and amantadine-treated groups; however, a significantly greater number of participants who took 200 mg of amantadine/day (16.9%) stopped medication during the trial as compared with the placebo groups (7.6%) (P < 0.02).</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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